Medicago’s bioactive molecule products – defined as compounds that have an effect on a living organism, tissue or cell – include bioactive proteins such as Protein A and Calmodulin, as well as saponin. All products are characterized by their high share of active molecules.
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Medicago’s bioactive molecules are delivered as freeze-dried powdersmanufactured according to ISO 9001 with certain critical production processes carried out in clean rooms. If you don't find the product you are looking for in our web shop, we can most likely produce it for you. Contact us to discuss the appropriate development and/or manufacturing according to your specification.
IgG-binding protein
Protein A orginates from Staphylococcus aureus and has five antibody binding domains and one cell binding domain. It binds IgG from most mammalian species and some IgA and IgM through the Fc region.
Purification of monoclonal antibodies
Chromatographic separation using protein A immobilized on porous substrates is a common method to purify monoclonal antibodies. Medicago's Protein A product has a high specificity towards a wide range of immunogobulins.
Recombinant form, PAII
Medicago’s recombinant protein A, PAII, is produced in E. coli using animal-free media. The recombinant form has the cell-binding domain removed, for reduced non-specific binding and leakage.
Swedish bovine origin
Calmodulin is a bioactive protein isolated from bovine testes. The material is derived from individually marked animals born and raised in Sweden, a country where BSE has not been a problem historically.
Affecting cellular processes
Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.
Calcium sensor and signal transducer
Calmodulin is used by many proteins as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered.
Soapy properties
Saponins are amphiphilic glycosides widely distributed in nature. They are both water and fat soluble, which gives them their useful soapy properties. In fact, their name is derived from their soapy characteristics, ”sapon” meaning ”soap” in Latin.
Highest hemolytic activity
Medicago’s saponin product is a mixture of different saponins with the highest hemolytic activity, extracted from the roots of Gypsophila oldhamiana. Our saponin is renowned for its unusually strong hemolytical activity.
Wide application range
Saponins are used commercially in dietary supplements and nutriceuticals and as adjuvants in vaccine preparations. Due to its strong hemolytic activity, Medicago’s saponin is also used extensively in blood sampling applications (länk till applications/blood sampling) including anything from clinical research to point-of-care equiment manufacturing.
Very high purity
Our saponin is unique for its high purity, which is achieved by performing more – and more extensive – chromatography purification steps than normal. We control the entire production chain – from processing and refining the raw material (the root of Gypsophila oldhamiana) to production of the finished, freeze-dried product.
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