Medicago’s bioactive molecules - compounds having an effect within a living organism, tissue, or cell - include proteins such as Protein A, Calmodulin, and saponin. All of Medicago's bioactive proteins retain high proportions of active constituents.
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IgG-binding protein
Protein A orginates from Staphylococcus aureus and has five antibody binding domains and one cell binding domain. It binds IgG from most mammalian species and some IgA and IgM through the Fc region.
Purification of monoclonal antibodies
Chromatographic separation using protein A immobilized on porous substrates is a common method to purify monoclonal antibodies. Medicago's Protein A product has a high specificity towards a wide range of immunogobulins.
Recombinant form, PAII
Medicago’s recombinant protein A, PAII, is produced in E. coli using animal-free media. The recombinant form has the cell-binding domain removed, for reduced non-specific binding and leakage.
Produced from Swedish cows!
Calmodulin is a bioactive protein isolated from bovine testes. Individually marked animals born and raised in Sweden are the sole source of Medicago’s Calmodulin. .
A key mediator of cellular processes
Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.
Calcium sensor and signal transducer
Calmodulin is used by many proteins as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered.
Soaplike properties
Saponins are amphiphilic glycosides widely distributed in nature. Capable of dissolving both hydrophobic and hydrophilic species, the name derives from Latin for soap: sapon.
High hemolytic activity
Medicago’s Saponin is a mixture of several varieties of saponin extracted from G. oldhamiana, exhibiting high capabilites for cleaving erythrocytes, or hemolytic activity.
Wide application range
Saponins are available commerically as dietary supplements and in adjuvants for vaccine preparations. Medicago’s Saponin possesses a high degree of hemolytic activity and hence finds application in a range of blood sampling procedures.
Exceptional purity
Our chromatographic purification protocol includes several crucial, extra steps to ensure an exceptionally high purity of our final Saponin product. We control the entire production of Saponin from initial processing and refinement of G. oldhamiana to freeze drying of column eluates.
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